Louse
TrinketAfterbirthUnlocked
How do you unlock Louse?
Verified starting unlockSource data confirms that no unlock is required.
Occasionally spawns a Blue Spider. [Repentance+] Spawns a Blue Spider when completing a combat room.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Louse leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13