
Mother's Kiss
TrinketRepentanceLocked
How do you unlock Mother's Kiss?
In The Binding of Isaac, Mother's Kiss is unlocked by earning the Mother completion mark as Tainted Magdalene.
Structured pathSource-backed requirements are mapped into trackable steps.
Grants one heart container.
- Defeat Hush 3 times to unlock A Secret Exit. source
- After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
- Collect Knife Piece 1 in Downpour/Dross II. source
- Collect Knife Piece 2 in Mines/Ashpit II. source
- After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
- Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
What unlocking Mother's Kiss leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13