Panic Button
TrinketRepentanceUnlocked
How do you unlock Panic Button?
Verified starting unlockSource data confirms that no unlock is required.
Activates Isaac's active item just before he takes damage.
Available from the start
No unlock needed — this is available in every new save file.
What unlocking Panic Button leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13