Stem Cell

TrinketAfterbirth+Locked

How do you unlock Stem Cell?

In The Binding of Isaac, Stem Cell is unlocked by earning the Ultra Greedier completion mark as Samson (Character) on hard mode.

Structured pathSource-backed requirements are mapped into trackable steps.

[Before Repentance] Heals Isaac for a Half Red Heart upon traveling to the next floor. / [Repentance] Heals 50% of Isaac's empty Red Heart containers upon traveling to the next floor.

Stem Cell (Achievement)
- Samson (Character) → Ultra Greedier (hard)
  - Samson (Character)

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What unlocking Stem Cell leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13