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Strange Key

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How do you unlock Strange Key?

In The Binding of Isaac, Strange Key is unlocked by earning every normal-mode completion mark as Tainted Eve.

Structured pathSource-backed requirements are mapped into trackable steps.

Unlocks the passageway to ??? and the Hush fight, regardless of the run duration. Using Pandora's Box grants it a special effect, consuming the key.

See the full unlock path for Strange Key — 7 steps

Strange Key (Achievement)
- All of
  - Tainted Eve → Isaac (normal)
  - Tainted Eve → ??? (normal)
  - Tainted Eve → Satan (normal)
  - Tainted Eve → The Lamb (normal)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source

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What unlocking Strange Key leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13