Pica Run
ChallengeRepentanceLocked
Challenge details
- Challenge number
- 41
- Description
- All items are replaced by random trinkets. Marbles activates on every hit.
How do you unlock Pica Run?
In The Binding of Isaac, Pica Run is unlocked by reaching 11 defeat mom's heart or it lives! and unlocking Marbles (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
All items are replaced by random trinkets. Marbles activates on every hit.
- All of
- Defeat Mom's Heart or It Lives! (0/11)
How to unlock: Use 5 Gulp! pills in one run
What unlocking Pica Run leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13