D100

ItemRebirthLocked

activeGame ID 283★★★★

How do you unlock D100?

In The Binding of Isaac, D100 is unlocked by earning the Boss Rush completion mark as The Lost (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

[Before Repentance] Activates the combined effects of D4, The D6, and D20. / [Repentance] Activates the combined effects of D1, D4, The D6, D7, D8, D10, D12, and D20.

See the full unlock path for D100 — 9 steps

The D100
- The Lost (Character) → Boss Rush (normal)
  - The Lost (Character)

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What unlocking D100 leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13