The Lost

RebirthLocked

How do you unlock The Lost?

In The Binding of Isaac, The Lost is unlocked by unlocking Missing Poster (Trinket) and unlocking Die in a Sacrifice Room with Missing Poster.

Structured pathSource-backed requirements are mapped into trackable steps.

Unlocked by dying in a Sacrifice Room while holding the Missing Poster trinket.

See the full unlock path for The Lost — 6 steps

The Lost (Achievement)
- All of
  - Missing Poster (Trinket)
  - Die in a Sacrifice Room with Missing Poster

Show full path Show missing

Completion marks

Mom's Heart or It Lives!
Isaac
???
Satan
The Lamb
Mega Satan
Boss Rush
Hush
Ultra Greed
Delirium
Mother
The Beast

What unlocking The Lost leads to

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13

Unlock method changed after the original Rebirth release: originally required dying 4 times in a row as four different characters, each in a specific circumstance (e.g. Isaac to Mulliboom, Magdalene to self-damage from a bomb, Judas to Mom, Azazel to Satan); this was replaced by the current Missing Poster/Sacrifice Room method.