Isaac's Heart
AchievementRebirthUnlock unknown
Achievement details
- Achievement number
- 129
- Description
- Unlocked a new item.
- Requirement
- Defeat Isaac as The Lost
How do you unlock Isaac's Heart?
In The Binding of Isaac, Isaac's Heart is unlocked by earning the Isaac completion mark as The Lost (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Unlocked a new item.
See the full unlock path for Isaac's Heart — 8 stepsWhat unlocking Isaac's Heart leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13