Dead God

How to unlock: Have 7 or more Red Heart Containers at one time

How to unlock: Hold 55 Coins at one time

• Satan

  Defeat Satan

• Mom

  Defeat Mom

• Mom

  Defeat Mom

• Mom

  Defeat Mom

How to unlock: Defeat a Harbinger

• Defeat Mom's Heart or It Lives! (0/3)

• Azazel (Character) → Boss Rush (normal)

• Defeat Mom's Heart or It Lives! (0/8)

• Defeat Mom's Heart or It Lives! (0/9)

How to unlock: Destroy 100 Tinted Rocks

How to unlock: Beat Chapter 1

How to unlock: Beat Chapter 2

• Lokii

  Defeat Lokii

How to unlock: Beat Basement 40 times

How to unlock: Beat Chapter 2 30 times

How to unlock: Beat Chapter 3 20 times

How to unlock: Make a Super Bandage Girl by picking up 4 copies of Ball of Bandages in one run

• Magdalene (Character) → Isaac (normal)

• Cain (Character) → Isaac (normal)

How to unlock: Defeat all 7 Deadly Sins

• Gish

  Defeat Gish

• Steven

  Defeat Steven

• C.H.A.D.

  Defeat C.H.A.D.

How to unlock: Visit 10 Arcades

How to unlock: Defeat Mom, Mom's Heart, or It Lives! using The Bible or XV - The Devil?

How to unlock: Destroy 10 Tinted Rocks

• ??? (Character) → Isaac (normal)

How to unlock: Die 100 times

How to unlock: Pick up 2 dead-related items in a single run

• Defeat Mom's Heart or It Lives! (0/10)

• Defeat Mom's Heart or It Lives! (0/5)

• Defeat Mom's Heart or It Lives! (0/11)

How to unlock: Obtain three Yes Mother? items in one run

How to unlock: Use XIII - Death 4 times

How to unlock: Beat Chapter 1 without taking damage

How to unlock: Beat Chapter 2 without taking damage

How to unlock: Beat Chapter 3 without taking damage

How to unlock: Beat Chapter 4 without taking damage

• All of

How to unlock: Don't pick up any hearts for 2 floors in a row

• Isaac (Character) → Satan (normal)

• Eve (Character) → Satan (normal)

• Magdalene (Character) → Satan (normal)

• Cain (Character) → Satan (normal)

• Azazel (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• ??? (Character) → Satan (normal)

• Isaac (Character) → ??? (normal)

• Magdalene (Character) → ??? (normal)

• Cain (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Judas (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Eve (Character) → ??? (normal)

• Samson (Character) → Isaac (normal)

• Samson (Character) → ??? (normal)

• Samson (Character) → Satan (normal)

How to unlock: Defeat Isaac 5 times

How to unlock: Pick up both Key Pieces from the Angels in one run

• Donate coins to the Donation Machine (0/900)

• Beans!

How to unlock: Blow up 20 Shopkeepers

• The Family Man (Challenge)

• It's in the Cards

How to unlock: Play either Shell Game or [Repentance] Hell Game 100 times

How to unlock: Become Guppy

How to unlock: Take 10 Angel Room items

How to unlock: Complete 2 floors in a row without taking damage

How to unlock: Defeat Isaac 10 times

How to unlock: Collect all non-DLC items, and unlock all non-DLC secrets and endings (minus The Lost and his 6 unlockable items)

• Isaac (Character) → Boss Rush (normal)

• Magdalene (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Judas (Character) → Satan (normal)

• ??? (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Samson (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Cain (Character) → ??? (normal)

• Eve (Character) → Isaac (normal)

How to unlock: Defeat Ultra Pride as any character, or ??? as Judas

How to unlock: Defeat Satan 5 times

How to unlock: Make 3 Deals with the Devil in one run

How to unlock: Have 4 or more Soul Hearts at one time

How to unlock: Complete Chapter 4

• All of

How to unlock: Complete Chapter 6 without taking damage

How to unlock: Collect all non-DLC items, and unlock all non-DLC secrets and endings

How to unlock: Destroy 100 rocks

How to unlock: Beat all Basement bosses

How to unlock: Beat all Caves bosses

How to unlock: Beat all Depths bosses

• Pitch Black

• High Brow

• Head Trauma

• Darkness Falls (Challenge)

• The Tank (Challenge)

• Solar System (Challenge)

• Purist (Challenge)

• Cat Got Your Tongue (Challenge)

• Demo Man (Challenge)

• Cursed! (Challenge)

• Glass Cannon (Challenge)

• When Life Gives You Lemons

• Slow Roll

• Computer Savvy

• Waka Waka

• The Host

• Lazarus (Character) → Boss Rush (normal)

• Isaac (Character) → Isaac (normal)

• Judas (Character) → Isaac (normal)

• Judas (Character) → Boss Rush (normal)

• Magdalene (Character) → Boss Rush (normal)

• Cain (Character) → Boss Rush (normal)

• Eve (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Eve (Character) → Boss Rush (normal)

• ??? (Character) → ??? (normal)

• ??? (Character) → Boss Rush (normal)

• Samson (Character) → Boss Rush (normal)

• Lazarus (Character) → Isaac (normal)

• Lazarus (Character) → Satan (normal)

• Lazarus (Character) → ??? (normal)

• Lazarus (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Suicide King (Challenge)

• Eden (Character) → Isaac (normal)

• Eden (Character) → Satan (normal)

• Eden (Character) → ??? (normal)

• Eden (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Eden (Character) → Boss Rush (normal)

• Azazel (Character) → Isaac (normal)

• Azazel (Character) → Satan (normal)

• Azazel (Character) → ??? (normal)

• The Lost (Character) → Isaac (normal)

• The Lost (Character) → Satan (normal)

• The Lost (Character) → ??? (normal)

• The Lost (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• The Lost (Character) → Boss Rush (normal)

• Donate coins to the Donation Machine (0/10)

• Donate coins to the Donation Machine (0/50)

• Donate coins to the Donation Machine (0/150)

• Donate coins to the Donation Machine (0/400)

• Donate coins to the Donation Machine (0/999)

• Defeat Mom's Heart or It Lives! (0/4)

• Defeat Mom's Heart or It Lives! (0/6)

• Defeat Mom's Heart or It Lives! (0/7)

How to unlock: Take 20 items from Devil Rooms

How to unlock: Defeat Krampus

How to unlock: Make a Super Meat Boy by picking up 4 copies of Cube of Meat in one run

How to unlock: Destroy 100 poops

How to unlock: Pick up 2 syringe-related items in a single run

How to unlock: Use the Blood Donation Machine 30 times

How to unlock: Blow up 30 Slot Machine

• Isaac (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Defeat Mom's Heart or It Lives! (0/2)

• Donate coins to the Donation Machine (0/20)

• Donate coins to the Donation Machine (0/100)

• Donate coins to the Donation Machine (0/200)

• Donate coins to the Donation Machine (0/600)

How to unlock: Complete Chapter 6

• All of

How to unlock: [before Repentance] Defeat Mom's Heart 11 times and unlock Eve / [Repentance] Defeat Mom's Heart 11 times and defeat ??? as Eve

How to unlock: Have 7 or more Red Heart Containers at one time

• Defeat Mom's Heart or It Lives! (0/3)

• All of

How to unlock: Become Guppy

• Defeat Mom's Heart or It Lives! (0/9)

How to unlock: Have 7 or more Red Heart Containers at one time

• All of

How to unlock: Pick up both Key Pieces from the Angels in one run

• Mom

  Defeat Mom

• Isaac (Character) → Mom's Heart or It Lives! (hard)

• Magdalene (Character) → Mom's Heart or It Lives! (hard)

• Eve (Character) → Mom's Heart or It Lives! (hard)

• Judas (Character) → Mom's Heart or It Lives! (hard)

• Cain (Character) → Mom's Heart or It Lives! (hard)

How to unlock: [before Afterbirth+] Defeat Mom's Heart or It Lives! on Hard mode as Azazel / [Afterbirth+] Defeat Mom's Heart or It Lives! on Hard mode as Lazarus

How to unlock: [before Afterbirth+] Defeat Mom's Heart or It Lives! on Hard mode as Lazarus / [Afterbirth+] Defeat Mom's Heart or It Lives! on Hard mode as Azazel

• ??? (Character) → Mom's Heart or It Lives! (hard)

• The Lost (Character) → Mom's Heart or It Lives! (hard)

• Eden (Character) → Mom's Heart or It Lives! (hard)

• Samson (Character) → Mom's Heart or It Lives! (hard)

How to unlock: Become Beelzebub

• Isaac (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Magdalene (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Cain (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Judas (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• ??? (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Eve (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Samson (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Azazel (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Lazarus (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Eden (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• The Lost (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Lilith (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Keeper (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Isaac (Character) → Ultra Greed (normal)

• Magdalene (Character) → Ultra Greed (normal)

• Cain (Character) → Ultra Greed (normal)

• Judas (Character) → Ultra Greed (normal)

• ??? (Character) → Ultra Greed (normal)

• Eve (Character) → Ultra Greed (normal)

• Samson (Character) → Ultra Greed (normal)

• Azazel (Character) → Ultra Greed (normal)

• Lazarus (Character) → Ultra Greed (normal)

• Eden (Character) → Ultra Greed (normal)

• The Lost (Character) → Ultra Greed (normal)

• Lilith (Character) → Ultra Greed (normal)

• Keeper (Character) → Ultra Greed (normal)

• Isaac (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Magdalene (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Cain (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Judas (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• ??? (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Eve (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Samson (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Azazel (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Lazarus (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Eden (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• The Lost (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Lilith (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Keeper (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Lilith (Character) → Isaac (normal)

• Lilith (Character) → ??? (normal)

• Lilith (Character) → Satan (normal)

• Lilith (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Lilith (Character) → Boss Rush (normal)

• Lilith (Character) → Mom's Heart or It Lives! (hard)

• XXXXXXXXL (Challenge)

• SPEED! (Challenge)

• Blue Bomber (Challenge)

• PAY TO PLAY (Challenge)

• Have a Heart (Challenge)

• I RULE! (Challenge)

• BRAINS! (Challenge)

• PRIDE DAY! (Challenge)

How to unlock: [before Afterbirth+] Complete The Guardian (challenge #30) / [Afterbirth+] Complete Onan's Streak (challenge #29)

How to unlock: [before Afterbirth+] Complete Onan's Streak (challenge #29) / [Afterbirth+] Complete The Guardian (challenge #30)

• Defeat Mom's Heart or It Lives! (0/10)

How to unlock: [before Repentance] Unlock all Afterbirth secrets and endings, and collect every Afterbirth item / [Repentance] Unlock 275 random achievements and have at least 510 items in the collection page

• Keeper (Character) → Isaac (normal)

• Keeper (Character) → Satan (normal)

• Keeper (Character) → ??? (normal)

• Keeper (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Keeper (Character) → Boss Rush (normal)

• Keeper (Character) → Mom's Heart or It Lives! (hard)

• Donate coins to the Greed Donation Machine (0/2)

• Donate coins to the Greed Donation Machine (0/14)

• Donate coins to the Greed Donation Machine (0/33)

• Donate coins to the Greed Donation Machine (0/68)

• Donate coins to the Greed Donation Machine (0/111)

• Donate coins to the Greed Donation Machine (0/234)

• Donate coins to the Greed Donation Machine (0/439)

• Donate coins to the Greed Donation Machine (0/666)

• Donate coins to the Greed Donation Machine (0/879)

• Donate coins to the Greed Donation Machine (0/1000)

• All of

• All of

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How to unlock: Use Blank Card while holding XIX - The Sun

• All of

• All of

• All of

• All of

• All of

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• Mom

  Defeat Mom

• Mom

  Defeat Mom

How to unlock: Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times

How to unlock: Defeat Isaac as Cain [before Repentance+] and destroy 10 Tinted Rocks

• Mom

  Defeat Mom

How to unlock: [before Afterbirth+] Defeat ??? or The Lamb, defeat Satan as Isaac, and unlock The Negative / [Afterbirth+ before Repentance] Defeat ??? or The Lamb, and defeat Satan as Isaac / [Repentance] Defeat Mega Satan and unlock The Negative

How to unlock: Defeat Isaac 5 times

• Mom

  Defeat Mom

How to unlock: [Afterbirth before Repentance] Defeat Mom / [Repentance] Unlock Judas and It Lives!

• Mom

  Defeat Mom

• Donate coins to the Greed Donation Machine (0/999)

How to unlock: Defeat Mega Satan as every character ([Repentance] except tainted characters)

How to unlock: [before Repentance] Defeat ??? or The Lamb / [Repentance] Defeat Mega Satan and unlock The Negative

• Mom

  Defeat Mom

• Defeat Mom's Heart or It Lives! (0/11)

How to unlock: [before Repentance] Defeat ??? or The Lamb / [Repentance] Defeat Mega Satan and unlock The Negative

How to unlock: Defeat Isaac 5 times

• Isaac (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Magdalene (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Cain (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Judas (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• ??? (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Samson (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Eve (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Eden (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Azazel (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Lazarus (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Lilith (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• The Lost (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Keeper (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Apollyon (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• Isaac (Character) → Ultra Greedier (hard)

• Magdalene (Character) → Ultra Greedier (hard)

• Cain (Character) → Ultra Greedier (hard)

• Judas (Character) → Ultra Greedier (hard)

• ??? (Character) → Ultra Greedier (hard)

• Samson (Character) → Ultra Greedier (hard)

• Eve (Character) → Ultra Greedier (hard)

• Eden (Character) → Ultra Greedier (hard)

• Azazel (Character) → Ultra Greedier (hard)

• Lazarus (Character) → Ultra Greedier (hard)

• Lilith (Character) → Ultra Greedier (hard)

• The Lost (Character) → Ultra Greedier (hard)

• Keeper (Character) → Ultra Greedier (hard)

• Apollyon (Character) → Ultra Greedier (hard)

• Apollyon (Character) → Isaac (normal)

• Apollyon (Character) → Satan (normal)

• Apollyon (Character) → ??? (normal)

• Apollyon (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Apollyon (Character) → Boss Rush (normal)

• Apollyon (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Apollyon (Character) → Ultra Greed (normal)

• Apollyon (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Apollyon (Character) → Mom's Heart or It Lives! (hard)

• All of

• Hush

  Defeat Hush

How to unlock: Complete a Victory Lap by defeating The Lamb

• Build a win streak (0/3)

How to unlock: Get a 5-win streak, using a different character each time

How to unlock: Collect every entry in the Bestiary

• Participate in Daily Challenges (0/31)

How to unlock: Defeat The Lamb in under 20 minutes

How to unlock: Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run

How to unlock: Reset 7 times in a row / [Switch, PS4] Get a minus 10-win streak

How to unlock: Complete a Chapter (floors I and II) after Basement, start-to-finish, with only half a Heart total (can use The Lost)

How to unlock: Obtain 50 items in a run

• Backasswards (Challenge)

• Aprils Fool (Challenge)

• Pokey Mans (Challenge)

• Ultra Hard (Challenge)

• Pong (Challenge)

• Build a Daily Challenge win streak (0/5)

How to unlock: Complete 3 Victory Laps by defeating The Lamb

• Delirium

  Defeat Delirium

How to unlock: [before Repentance] Collect every item in the game, unlock all secrets and endings, and complete the Bestiary / [Repentance] Unlock 402 random achievements and have at least 510 items in the collection page

• Mega Satan

  Defeat Mega Satan

• Donate coins to the Greed Donation Machine (0/500)

• Defeat Mom's Heart or It Lives! (0/11)

• Defeat Mom's Heart or It Lives! (0/16)

• Defeat Mom's Heart or It Lives! (0/21)

• Defeat Mom's Heart or It Lives! (0/30)

How to unlock: Defeat ??? as 3 different Characters

How to unlock: Defeat ??? as 6 different Characters

• The Lamb

  Defeat The Lamb

How to unlock: Defeat 20 Portals

How to unlock: Destroy 500 rocks

How to unlock: Beat Chapter 1 without taking damage

How to unlock: Become Beelzebub

How to unlock: Destroy 5 rainbow poops

• Complete Daily Challenges (0/7)

How to unlock: Pick up 5 familiars in a single run

How to unlock: Defeat Little Horn 20 times

How to unlock: Defeat Delirium for the 1st time

How to unlock: Recharge using Lil' Batteries 20 times

How to unlock: Sleep in a bed

How to unlock: Complete 2 Victory Laps by defeating The Lamb

How to unlock: Be 3 times larger than the starting size. Depending on the item/card/pill size's multiplier, 5 to 7 size increases will be required.

How to unlock: Use Cards and Runes 20 times

How to unlock: Add both the Broken Watch and the Stop Watch to your collection

How to unlock: Purchase anything from Shops, Devil Rooms, and/or Black Markets 50 times

How to unlock: Beat Chapter 2 without taking damage

How to unlock: Use Pandora's Box in Dark Room

How to unlock: Pick up 2 battery-related items in a single run

How to unlock: Beat Chapter 3 without taking damage

How to unlock: Pick up 2 technology-related items in a single run

How to unlock: Acquire both Key Piece 1 and Key Piece 2

How to unlock: Open 20 Locked Chests

How to unlock: Defeat all 5 Harbingers

How to unlock: Defeat an Angel 10 times

How to unlock: Beat Chapter 4 without taking damage

How to unlock: Blow up doors and Secret Room walls 50 times

How to unlock: Take 25 Deals with the Devil

How to unlock: Acquire Blood Clot 10 times

How to unlock: Collect 10 "Tears Up" items or pills in one run

How to unlock: Enter 6 Shops in one run

How to unlock: Take 25 Angel Rooms items

How to unlock: Have The Battery, 9 Volt, and Car Battery in Isaac's collection

How to unlock: Acquire Rubber Cement 5 times

How to unlock: Take 50 Deals with the Devil

How to unlock: Have Isaac die to his own explosion from any explosive and poisoned tear (Ipecac, Bob's Rotten Head, Fire Mind / Explosivo + Scorpio, or a Horf! pill)

How to unlock: Sleep in 10 beds

How to unlock: Use 5 Gulp! pills in one run

How to unlock: Spawn three charmed enemies in the same room

How to unlock: Have 20 Blue Flies at the same time

How to unlock: Use I - The Magician or Telepathy For Dummies while already having homing tears

How to unlock: It's complicated

How to unlock: It's complicated

• The Forgotten (Character) → Mom's Heart or It Lives! (hard)

• The Forgotten (Character) → Isaac (normal)

• The Forgotten (Character) → Satan (normal)

• The Forgotten (Character) → ??? (normal)

• The Forgotten (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• The Forgotten (Character) → Boss Rush (normal)

• The Forgotten (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• The Forgotten (Character) → Ultra Greed (normal)

• The Forgotten (Character) → Ultra Greedier (hard)

• The Forgotten (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• All of

• The Forgotten (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

How to unlock: Defeat Mom's Heart or It Lives! on hard mode as Lazarus, without dying at all

• Mother

  Defeat Mother

How to unlock: Collect any 3 items with the 'stars' item tag in a single run

How to unlock: Defeat Hush 3 times

How to unlock: Blow up The Siren's skull after defeating her

How to unlock: Defeat Baby Plum 10 times

How to unlock: Allow Baby Plum to escape instead of defeating her

How to unlock: Enter Corpse for the first time

How to unlock: Defeat all bosses in Downpour

How to unlock: Defeat all bosses in Mines

How to unlock: Defeat all bosses in Mausoleum

How to unlock: Open Mom's Chest in Home

• Bethany (Character) → Mom's Heart or It Lives! (hard)

• Bethany (Character) → Isaac (normal)

• Bethany (Character) → Satan (normal)

• Bethany (Character) → ??? (normal)

• Bethany (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Bethany (Character) → Boss Rush (normal)

• Bethany (Character) → Ultra Greed (normal)

• Bethany (Character) → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Bethany (Character) → Ultra Greedier (hard)

• Bethany (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• All of

• Bethany (Character) → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Jacob & Esau → Mom's Heart or It Lives! (hard)

• Jacob & Esau → Isaac (normal)

• Jacob & Esau → Satan (normal)

• Jacob & Esau → ??? (normal)

• Jacob & Esau → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source

• Jacob & Esau → Boss Rush (normal)

• Jacob & Esau → Ultra Greed (normal)

• Jacob & Esau → Hush (normal)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source

• Jacob & Esau → Ultra Greedier (hard)

• Jacob & Esau → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source

• All of

• Jacob & Esau → Mega Satan (normal)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source

• Isaac (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Isaac (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Magdalene (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Magdalene (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Cain (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Cain (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Judas (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Judas (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• ??? (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• ??? (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Eve (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Eve (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Samson (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Samson (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Azazel (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Azazel (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Lazarus (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Lazarus (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Eden (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Eden (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• The Lost (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• The Lost (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Lilith (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Lilith (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Keeper (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Keeper (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• Apollyon (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source

• Apollyon (Character) → The Beast (normal)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

• The Forgotten (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source