Jacob & Esau
RepentanceLockedHow do you unlock Jacob & Esau?
In The Binding of Isaac, Jacob & Esau is unlocked by unlocking Mother.
Structured pathSource-backed requirements are mapped into trackable steps.
Unlocked by defeating Mother with any character.
Defeat Mother
Completion marks
Mom's Heart or It Lives!
Isaac
???
Satan
The Lamb
Mega Satan
Boss Rush
Hush
Ultra Greed
Delirium
Mother
The Beast
What unlocking Jacob & Esau leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13