Mega Mush

AchievementRepentanceUnlock unknown

Achievement details

Achievement number: 547
Description: Beat everything in Hard Mode as every character.
Requirement: Earn all Hard mode Completion Marks for all non-Tainted characters

How do you unlock Mega Mush?

In The Binding of Isaac, Mega Mush is unlocked by earning the Mom's Heart or It Lives! completion mark as Isaac (Character) on hard mode, earning the Isaac completion mark as Isaac (Character) on hard mode, and earning the ??? completion mark as Isaac (Character) on hard mode, and 201 more requirements.

Structured pathSource-backed requirements are mapped into trackable steps.

Beat everything in Hard Mode as every character.

See the full unlock path for Mega Mush — 247 steps

All of
- Isaac (Character) → Mom's Heart or It Lives! (hard)
  - Isaac (Character)
- Isaac (Character) → Isaac (hard)
  - Isaac (Character)
- Isaac (Character) → ??? (hard)
  - Isaac (Character)
- Isaac (Character) → Satan (hard)
  - Isaac (Character)
- Isaac (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Isaac (Character)
- Isaac (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Isaac (Character)
- Isaac (Character) → Boss Rush (hard)
  - Isaac (Character)
- Isaac (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Isaac (Character)
- Isaac (Character) → Ultra Greedier (hard)
  - Isaac (Character)
- Isaac (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Isaac (Character)
- Isaac (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Isaac (Character)
- Isaac (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Isaac (Character)
- Magdalene (Character) → Mom's Heart or It Lives! (hard)
  - Magdalene (Character)
- Magdalene (Character) → Isaac (hard)
  - Magdalene (Character)
- Magdalene (Character) → ??? (hard)
  - Magdalene (Character)
- Magdalene (Character) → Satan (hard)
  - Magdalene (Character)
- Magdalene (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Magdalene (Character)
- Magdalene (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Magdalene (Character)
- Magdalene (Character) → Boss Rush (hard)
  - Magdalene (Character)
- Magdalene (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Magdalene (Character)
- Magdalene (Character) → Ultra Greedier (hard)
  - Magdalene (Character)
- Magdalene (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Magdalene (Character)
- Magdalene (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Magdalene (Character)
- Magdalene (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Magdalene (Character)
- Cain (Character) → Mom's Heart or It Lives! (hard)
  - Cain (Character)
- Cain (Character) → Isaac (hard)
  - Cain (Character)
- Cain (Character) → ??? (hard)
  - Cain (Character)
- Cain (Character) → Satan (hard)
  - Cain (Character)
- Cain (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Cain (Character)
- Cain (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Cain (Character)
- Cain (Character) → Boss Rush (hard)
  - Cain (Character)
- Cain (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Cain (Character)
- Cain (Character) → Ultra Greedier (hard)
  - Cain (Character)
- Cain (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Cain (Character)
- Cain (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Cain (Character)
- Cain (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Cain (Character)
- Judas (Character) → Mom's Heart or It Lives! (hard)
  - Judas (Character)
- Judas (Character) → Isaac (hard)
  - Judas (Character)
- Judas (Character) → ??? (hard)
  - Judas (Character)
- Judas (Character) → Satan (hard)
  - Judas (Character)
- Judas (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Judas (Character)
- Judas (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Judas (Character)
- Judas (Character) → Boss Rush (hard)
  - Judas (Character)
- Judas (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Judas (Character)
- Judas (Character) → Ultra Greedier (hard)
  - Judas (Character)
- Judas (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Judas (Character)
- Judas (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Judas (Character)
- Judas (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Judas (Character)
- ??? (Character) → Mom's Heart or It Lives! (hard)
  - ??? (Character)
- ??? (Character) → Isaac (hard)
  - ??? (Character)
- ??? (Character) → ??? (hard)
  - ??? (Character)
- ??? (Character) → Satan (hard)
  - ??? (Character)
- ??? (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - ??? (Character)
- ??? (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - ??? (Character)
- ??? (Character) → Boss Rush (hard)
  - ??? (Character)
- ??? (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - ??? (Character)
- ??? (Character) → Ultra Greedier (hard)
  - ??? (Character)
- ??? (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - ??? (Character)
- ??? (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - ??? (Character)
- ??? (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - ??? (Character)
- Eve (Character) → Mom's Heart or It Lives! (hard)
  - Eve (Character)
- Eve (Character) → Isaac (hard)
  - Eve (Character)
- Eve (Character) → ??? (hard)
  - Eve (Character)
- Eve (Character) → Satan (hard)
  - Eve (Character)
- Eve (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Eve (Character)
- Eve (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Eve (Character)
- Eve (Character) → Boss Rush (hard)
  - Eve (Character)
- Eve (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Eve (Character)
- Eve (Character) → Ultra Greedier (hard)
  - Eve (Character)
- Eve (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Eve (Character)
- Eve (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Eve (Character)
- Eve (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Eve (Character)
- Samson (Character) → Mom's Heart or It Lives! (hard)
  - Samson (Character)
- Samson (Character) → Isaac (hard)
  - Samson (Character)
- Samson (Character) → ??? (hard)
  - Samson (Character)
- Samson (Character) → Satan (hard)
  - Samson (Character)
- Samson (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Samson (Character)
- Samson (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Samson (Character)
- Samson (Character) → Boss Rush (hard)
  - Samson (Character)
- Samson (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Samson (Character)
- Samson (Character) → Ultra Greedier (hard)
  - Samson (Character)
- Samson (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Samson (Character)
- Samson (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Samson (Character)
- Samson (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Samson (Character)
- Azazel (Character) → Mom's Heart or It Lives! (hard)
  - Azazel (Character)
- Azazel (Character) → Isaac (hard)
  - Azazel (Character)
- Azazel (Character) → ??? (hard)
  - Azazel (Character)
- Azazel (Character) → Satan (hard)
  - Azazel (Character)
- Azazel (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Azazel (Character)
- Azazel (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Azazel (Character)
- Azazel (Character) → Boss Rush (hard)
  - Azazel (Character)
- Azazel (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Azazel (Character)
- Azazel (Character) → Ultra Greedier (hard)
  - Azazel (Character)
- Azazel (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Azazel (Character)
- Azazel (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Azazel (Character)
- Azazel (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Azazel (Character)
- Lazarus (Character) → Mom's Heart or It Lives! (hard)
  - Lazarus (Character)
- Lazarus (Character) → Isaac (hard)
  - Lazarus (Character)
- Lazarus (Character) → ??? (hard)
  - Lazarus (Character)
- Lazarus (Character) → Satan (hard)
  - Lazarus (Character)
- Lazarus (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Lazarus (Character)
- Lazarus (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Lazarus (Character)
- Lazarus (Character) → Boss Rush (hard)
  - Lazarus (Character)
- Lazarus (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Lazarus (Character)
- Lazarus (Character) → Ultra Greedier (hard)
  - Lazarus (Character)
- Lazarus (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Lazarus (Character)
- Lazarus (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Lazarus (Character)
- Lazarus (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Lazarus (Character)
- Eden (Character) → Mom's Heart or It Lives! (hard)
  - Eden (Character)
- Eden (Character) → Isaac (hard)
  - Eden (Character)
- Eden (Character) → ??? (hard)
  - Eden (Character)
- Eden (Character) → Satan (hard)
  - Eden (Character)
- Eden (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Eden (Character)
- Eden (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Eden (Character)
- Eden (Character) → Boss Rush (hard)
  - Eden (Character)
- Eden (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Eden (Character)
- Eden (Character) → Ultra Greedier (hard)
  - Eden (Character)
- Eden (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Eden (Character)
- Eden (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Eden (Character)
- Eden (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Eden (Character)
- The Lost (Character) → Mom's Heart or It Lives! (hard)
  - The Lost (Character)
- The Lost (Character) → Isaac (hard)
  - The Lost (Character)
- The Lost (Character) → ??? (hard)
  - The Lost (Character)
- The Lost (Character) → Satan (hard)
  - The Lost (Character)
- The Lost (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - The Lost (Character)
- The Lost (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - The Lost (Character)
- The Lost (Character) → Boss Rush (hard)
  - The Lost (Character)
- The Lost (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - The Lost (Character)
- The Lost (Character) → Ultra Greedier (hard)
  - The Lost (Character)
- The Lost (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - The Lost (Character)
- The Lost (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - The Lost (Character)
- The Lost (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - The Lost (Character)
- Lilith (Character) → Mom's Heart or It Lives! (hard)
  - Lilith (Character)
- Lilith (Character) → Isaac (hard)
  - Lilith (Character)
- Lilith (Character) → ??? (hard)
  - Lilith (Character)
- Lilith (Character) → Satan (hard)
  - Lilith (Character)
- Lilith (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Lilith (Character)
- Lilith (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Lilith (Character)
- Lilith (Character) → Boss Rush (hard)
  - Lilith (Character)
- Lilith (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Lilith (Character)
- Lilith (Character) → Ultra Greedier (hard)
  - Lilith (Character)
- Lilith (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Lilith (Character)
- Lilith (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Lilith (Character)
- Lilith (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Lilith (Character)
- Keeper (Character) → Mom's Heart or It Lives! (hard)
  - Keeper (Character)
- Keeper (Character) → Isaac (hard)
  - Keeper (Character)
- Keeper (Character) → ??? (hard)
  - Keeper (Character)
- Keeper (Character) → Satan (hard)
  - Keeper (Character)
- Keeper (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Keeper (Character)
- Keeper (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Keeper (Character)
- Keeper (Character) → Boss Rush (hard)
  - Keeper (Character)
- Keeper (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Keeper (Character)
- Keeper (Character) → Ultra Greedier (hard)
  - Keeper (Character)
- Keeper (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Keeper (Character)
- Keeper (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Keeper (Character)
- Keeper (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Keeper (Character)
- Apollyon (Character) → Mom's Heart or It Lives! (hard)
  - Apollyon (Character)
- Apollyon (Character) → Isaac (hard)
  - Apollyon (Character)
- Apollyon (Character) → ??? (hard)
  - Apollyon (Character)
- Apollyon (Character) → Satan (hard)
  - Apollyon (Character)
- Apollyon (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Apollyon (Character)
- Apollyon (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Apollyon (Character)
- Apollyon (Character) → Boss Rush (hard)
  - Apollyon (Character)
- Apollyon (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Apollyon (Character)
- Apollyon (Character) → Ultra Greedier (hard)
  - Apollyon (Character)
- Apollyon (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Apollyon (Character)
- Apollyon (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Apollyon (Character)
- Apollyon (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Apollyon (Character)
- The Forgotten (Character) → Mom's Heart or It Lives! (hard)
  - The Forgotten (Character)
- The Forgotten (Character) → Isaac (hard)
  - The Forgotten (Character)
- The Forgotten (Character) → ??? (hard)
  - The Forgotten (Character)
- The Forgotten (Character) → Satan (hard)
  - The Forgotten (Character)
- The Forgotten (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - The Forgotten (Character)
- The Forgotten (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - The Forgotten (Character)
- The Forgotten (Character) → Boss Rush (hard)
  - The Forgotten (Character)
- The Forgotten (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - The Forgotten (Character)
- The Forgotten (Character) → Ultra Greedier (hard)
  - The Forgotten (Character)
- The Forgotten (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - The Forgotten (Character)
- The Forgotten (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - The Forgotten (Character)
- The Forgotten (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - The Forgotten (Character)
- Bethany (Character) → Mom's Heart or It Lives! (hard)
  - Bethany (Character)
- Bethany (Character) → Isaac (hard)
  - Bethany (Character)
- Bethany (Character) → ??? (hard)
  - Bethany (Character)
- Bethany (Character) → Satan (hard)
  - Bethany (Character)
- Bethany (Character) → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Bethany (Character)
- Bethany (Character) → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Bethany (Character)
- Bethany (Character) → Boss Rush (hard)
  - Bethany (Character)
- Bethany (Character) → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Bethany (Character)
- Bethany (Character) → Ultra Greedier (hard)
  - Bethany (Character)
- Bethany (Character) → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Bethany (Character)
- Bethany (Character) → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Bethany (Character)
- Bethany (Character) → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Bethany (Character)
- Jacob & Esau → Mom's Heart or It Lives! (hard)
  - Jacob & Esau
- Jacob & Esau → Isaac (hard)
  - Jacob & Esau
- Jacob & Esau → ??? (hard)
  - Jacob & Esau
- Jacob & Esau → Satan (hard)
  - Jacob & Esau
- Jacob & Esau → The Lamb (hard)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Jacob & Esau
- Jacob & Esau → Mega Satan (hard)
  1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
  2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
  3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Jacob & Esau
- Jacob & Esau → Boss Rush (hard)
  - Jacob & Esau
- Jacob & Esau → Hush (hard)
  1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
  2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
  3. Defeat Hush in Blue Womb. source
  - Jacob & Esau
- Jacob & Esau → Ultra Greedier (hard)
  - Jacob & Esau
- Jacob & Esau → Delirium (hard)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - Jacob & Esau
- Jacob & Esau → Mother (hard)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Jacob & Esau
- Jacob & Esau → The Beast (hard)
  1. A Strange Door is unlocked by beating Mother for the first time. source
  2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
  3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Jacob & Esau

Show full path Show missing

What unlocking Mega Mush leads to

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13