Mega Mush

ItemRepentanceLocked

activeGame ID 625★★★★

How do you unlock Mega Mush?

In The Binding of Isaac, Mega Mush is unlocked by earning the Mom's Heart or It Lives! completion mark as Isaac (Character) on hard mode, earning the Isaac completion mark as Isaac (Character) on hard mode, and earning the ??? completion mark as Isaac (Character) on hard mode, and 201 more requirements.

Structured pathSource-backed requirements are mapped into trackable steps.

Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.

See the full unlock path for Mega Mush — 248 steps

Mega Mush (Achievement)
- All of
  - Isaac (Character) → Mom's Heart or It Lives! (hard)
  - Isaac (Character) → Isaac (hard)
  - Isaac (Character) → ??? (hard)
  - Isaac (Character) → Satan (hard)
  - Isaac (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Isaac (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Isaac (Character) → Boss Rush (hard)
  - Isaac (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Isaac (Character) → Ultra Greedier (hard)
  - Isaac (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Isaac (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Isaac (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Magdalene (Character) → Mom's Heart or It Lives! (hard)
  - Magdalene (Character) → Isaac (hard)
  - Magdalene (Character) → ??? (hard)
  - Magdalene (Character) → Satan (hard)
  - Magdalene (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Magdalene (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Magdalene (Character) → Boss Rush (hard)
  - Magdalene (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Magdalene (Character) → Ultra Greedier (hard)
  - Magdalene (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Magdalene (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Magdalene (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Cain (Character) → Mom's Heart or It Lives! (hard)
  - Cain (Character) → Isaac (hard)
  - Cain (Character) → ??? (hard)
  - Cain (Character) → Satan (hard)
  - Cain (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Cain (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Cain (Character) → Boss Rush (hard)
  - Cain (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Cain (Character) → Ultra Greedier (hard)
  - Cain (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Cain (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Cain (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Judas (Character) → Mom's Heart or It Lives! (hard)
  - Judas (Character) → Isaac (hard)
  - Judas (Character) → ??? (hard)
  - Judas (Character) → Satan (hard)
  - Judas (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Judas (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Judas (Character) → Boss Rush (hard)
  - Judas (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Judas (Character) → Ultra Greedier (hard)
  - Judas (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Judas (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Judas (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - ??? (Character) → Mom's Heart or It Lives! (hard)
  - ??? (Character) → Isaac (hard)
  - ??? (Character) → ??? (hard)
  - ??? (Character) → Satan (hard)
  - ??? (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - ??? (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - ??? (Character) → Boss Rush (hard)
  - ??? (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - ??? (Character) → Ultra Greedier (hard)
  - ??? (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - ??? (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - ??? (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Eve (Character) → Mom's Heart or It Lives! (hard)
  - Eve (Character) → Isaac (hard)
  - Eve (Character) → ??? (hard)
  - Eve (Character) → Satan (hard)
  - Eve (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Eve (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Eve (Character) → Boss Rush (hard)
  - Eve (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Eve (Character) → Ultra Greedier (hard)
  - Eve (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Eve (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Eve (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Samson (Character) → Mom's Heart or It Lives! (hard)
  - Samson (Character) → Isaac (hard)
  - Samson (Character) → ??? (hard)
  - Samson (Character) → Satan (hard)
  - Samson (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Samson (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Samson (Character) → Boss Rush (hard)
  - Samson (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Samson (Character) → Ultra Greedier (hard)
  - Samson (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Samson (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Samson (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Azazel (Character) → Mom's Heart or It Lives! (hard)
  - Azazel (Character) → Isaac (hard)
  - Azazel (Character) → ??? (hard)
  - Azazel (Character) → Satan (hard)
  - Azazel (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Azazel (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Azazel (Character) → Boss Rush (hard)
  - Azazel (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Azazel (Character) → Ultra Greedier (hard)
  - Azazel (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Azazel (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Azazel (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Lazarus (Character) → Mom's Heart or It Lives! (hard)
  - Lazarus (Character) → Isaac (hard)
  - Lazarus (Character) → ??? (hard)
  - Lazarus (Character) → Satan (hard)
  - Lazarus (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Lazarus (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Lazarus (Character) → Boss Rush (hard)
  - Lazarus (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Lazarus (Character) → Ultra Greedier (hard)
  - Lazarus (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Lazarus (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Lazarus (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Eden (Character) → Mom's Heart or It Lives! (hard)
  - Eden (Character) → Isaac (hard)
  - Eden (Character) → ??? (hard)
  - Eden (Character) → Satan (hard)
  - Eden (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Eden (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Eden (Character) → Boss Rush (hard)
  - Eden (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Eden (Character) → Ultra Greedier (hard)
  - Eden (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Eden (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Eden (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - The Lost (Character) → Mom's Heart or It Lives! (hard)
  - The Lost (Character) → Isaac (hard)
  - The Lost (Character) → ??? (hard)
  - The Lost (Character) → Satan (hard)
  - The Lost (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - The Lost (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - The Lost (Character) → Boss Rush (hard)
  - The Lost (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - The Lost (Character) → Ultra Greedier (hard)
  - The Lost (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - The Lost (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - The Lost (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Lilith (Character) → Mom's Heart or It Lives! (hard)
  - Lilith (Character) → Isaac (hard)
  - Lilith (Character) → ??? (hard)
  - Lilith (Character) → Satan (hard)
  - Lilith (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Lilith (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Lilith (Character) → Boss Rush (hard)
  - Lilith (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Lilith (Character) → Ultra Greedier (hard)
  - Lilith (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Lilith (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Lilith (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Keeper (Character) → Mom's Heart or It Lives! (hard)
  - Keeper (Character) → Isaac (hard)
  - Keeper (Character) → ??? (hard)
  - Keeper (Character) → Satan (hard)
  - Keeper (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Keeper (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Keeper (Character) → Boss Rush (hard)
  - Keeper (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Keeper (Character) → Ultra Greedier (hard)
  - Keeper (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Keeper (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Keeper (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Apollyon (Character) → Mom's Heart or It Lives! (hard)
  - Apollyon (Character) → Isaac (hard)
  - Apollyon (Character) → ??? (hard)
  - Apollyon (Character) → Satan (hard)
  - Apollyon (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Apollyon (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Apollyon (Character) → Boss Rush (hard)
  - Apollyon (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Apollyon (Character) → Ultra Greedier (hard)
  - Apollyon (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Apollyon (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Apollyon (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - The Forgotten (Character) → Mom's Heart or It Lives! (hard)
  - The Forgotten (Character) → Isaac (hard)
  - The Forgotten (Character) → ??? (hard)
  - The Forgotten (Character) → Satan (hard)
  - The Forgotten (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - The Forgotten (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - The Forgotten (Character) → Boss Rush (hard)
  - The Forgotten (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - The Forgotten (Character) → Ultra Greedier (hard)
  - The Forgotten (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - The Forgotten (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - The Forgotten (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Bethany (Character) → Mom's Heart or It Lives! (hard)
  - Bethany (Character) → Isaac (hard)
  - Bethany (Character) → ??? (hard)
  - Bethany (Character) → Satan (hard)
  - Bethany (Character) → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Bethany (Character) → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Bethany (Character) → Boss Rush (hard)
  - Bethany (Character) → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Bethany (Character) → Ultra Greedier (hard)
  - Bethany (Character) → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Bethany (Character) → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Bethany (Character) → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source
  - Jacob & Esau → Mom's Heart or It Lives! (hard)
  - Jacob & Esau → Isaac (hard)
  - Jacob & Esau → ??? (hard)
  - Jacob & Esau → Satan (hard)
  - Jacob & Esau → The Lamb (hard)
    1. Defeat Satan 5 times to unlock The Negative. source
    2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
    3. Find and defeat The Lamb in Dark Room. source
  - Jacob & Esau → Mega Satan (hard)
    1. ??? or The Lamb must be defeated once for the Golden Gate to spawn. source
    2. Open the Golden Gate by combining Key Piece 1 and Key Piece 2 into the Golden Key, or by using Dad's Key or another gate-opening effect. source
    3. Reach the starting room of Chest or Dark Room, pass through the Golden Gate, and defeat Mega Satan. source
  - Jacob & Esau → Boss Rush (hard)
  - Jacob & Esau → Hush (hard)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Jacob & Esau → Ultra Greedier (hard)
  - Jacob & Esau → Delirium (hard)
    1. Defeat Hush to unlock The Void. source
    2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
    3. Defeat Delirium, the main boss of The Void. source
  - Jacob & Esau → Mother (hard)
    1. Defeat Hush 3 times to unlock A Secret Exit. source
    2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
    3. Collect Knife Piece 1 in Downpour/Dross II. source
    4. Collect Knife Piece 2 in Mines/Ashpit II. source
    5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
    6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Jacob & Esau → The Beast (hard)
    1. A Strange Door is unlocked by beating Mother for the first time. source
    2. Take The Polaroid or The Negative after Mom, escape the boss room, then use it to open A Strange Door. source
    3. Find Dad's Note, complete the Ascent to Home, then defeat Dogma, the Ultra Harbingers, and The Beast. source

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What unlocking Mega Mush leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13