Cain
RebirthLockedHow do you unlock Cain?
In The Binding of Isaac, Cain is unlocked by unlocking Cain (Achievement).
Structured pathSource-backed requirements are mapped into trackable steps.
Unlocked by holding 55 or more coins at one time in a single run.
How to unlock: Hold 55 Coins at one time
Completion marks
Mom's Heart or It Lives!
Isaac
???
Satan
The Lamb
Mega Satan
Boss Rush
Hush
Ultra Greed
Delirium
Mother
The Beast
What unlocking Cain leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13