Apollyon
Afterbirth+LockedHow do you unlock Apollyon?
In The Binding of Isaac, Apollyon is unlocked by unlocking Mega Satan.
Structured pathSource-backed requirements are mapped into trackable steps.
Unlocked by defeating Mega Satan for the first time.
Defeat Mega Satan
Completion marks
Mom's Heart or It Lives!
Isaac
???
Satan
The Lamb
Mega Satan
Boss Rush
Hush
Ultra Greed
Delirium
Mother
The Beast
What unlocking Apollyon leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13