Tainted Apollyon
RepentanceTaintedLockedHow do you unlock Tainted Apollyon?
In The Binding of Isaac, Tainted Apollyon is unlocked by unlocking The Empty.
Structured pathSource-backed requirements are mapped into trackable steps.
Unlocked by using the Red Key, Cracked Key, or Soul of Cain to open the hidden closet in Home while playing as Apollyon.
How to unlock: Use Red Key (etc.) to open the hidden closet in Home as Apollyon
Completion marks
Mom's Heart or It Lives!
Isaac
???
Satan
The Lamb
Mega Satan
Boss Rush
Hush
Ultra Greed
Delirium
Mother
The Beast
What unlocking Tainted Apollyon leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13