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Pandora's Box

AchievementRebirthUnlock unknown

Achievement details

Achievement number: 119
Description: Unlocked a new item.
Requirement: Defeat The Lamb as Lazarus

How do you unlock Pandora's Box?

In The Binding of Isaac, Pandora's Box is unlocked by earning the The Lamb completion mark as Lazarus (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Unlocked a new item.

Lazarus (Character) → The Lamb (normal)
1. Defeat Satan 5 times to unlock The Negative. source
2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
3. Find and defeat The Lamb in Dark Room. source
- Lazarus (Character)
  - Lazarus (Achievement)
    How to unlock: Have 4 or more Soul Hearts at one time

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What unlocking Pandora's Box leads to

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13