Pandora's Box
ItemRebirthLocked
activeGame ID 297★★★★
How do you unlock Pandora's Box?
In The Binding of Isaac, Pandora's Box is unlocked by earning the The Lamb completion mark as Lazarus (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Spawns specific pickups or items depending on the floor it is used on. Disappears after use.
What unlocking Pandora's Box leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13