Progression route

The Path to Pandora's Box

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The path to unlock Pandora's Box in The Binding of Isaac has 4 steps.

4 requirements remaining0%

Path progress

Paths end with clear instructions for actions that cannot be tracked automatically.

Next steps

Lazarus (Achievement)
Lazarus (Character)
Lazarus (Character) → The Lamb (normal)

Pandora's Box (Item)

Pandora's Box (Achievement)

Lazarus → The Lamb

How to reach The Lamb: Defeat Satan 5 times to unlock The Negative. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. Find and defeat The Lamb in Dark Room.

Lazarus (Character)

Lazarus (Achievement)

How to unlock: Have 4 or more Soul Hearts at one time

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