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Holy Card

AchievementAfterbirth+Unlock unknown

Achievement details

Achievement number: 293
Description: Unlocked a new item.
Requirement: Defeat Delirium as The Lost

How do you unlock Holy Card?

In The Binding of Isaac, Holy Card is unlocked by earning the Delirium completion mark as The Lost (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Unlocked a new item.

See the full unlock path for Holy Card — 8 steps

The Lost (Character) → Delirium (normal)
1. Defeat Hush to unlock The Void. source
2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
3. Defeat Delirium, the main boss of The Void. source
- The Lost (Character)
  - The Lost (Achievement)

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What unlocking Holy Card leads to

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13