Holy Card

CardAfterbirth+Locked

How do you unlock Holy Card?

In The Binding of Isaac, Holy Card is unlocked by earning the Delirium completion mark as The Lost (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Grants a shield that blocks the next hostile damage that would be taken in the current room. Has a chance to spawn another Holy Card on use. Grants a shield that blocks the next hostile damage that would be taken.

See the full unlock path for Holy Card — 9 steps

Holy Card (Achievement)
- The Lost (Character) → Delirium (normal)
  1. Defeat Hush to unlock The Void. source
  2. A Void portal can appear after a major boss; defeating Hush guarantees one. source
  3. Defeat Delirium, the main boss of The Void. source
  - The Lost (Character)

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What unlocking Holy Card leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13