Rune of Perthro
AchievementRebirthUnlock unknown
Achievement details
- Achievement number
- 94
- Description
- Unlocked a new item.
- Requirement
- Complete Solar System (challenge #6)
How do you unlock Rune of Perthro?
In The Binding of Isaac, Rune of Perthro is unlocked by unlocking Solar System (Challenge).
Structured pathSource-backed requirements are mapped into trackable steps.
Unlocked a new item.
- Defeat Mom's Heart or It Lives! (0/3)
What unlocking Rune of Perthro leads to
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13