Perthro
RuneRebirthLocked
How do you unlock Perthro?
In The Binding of Isaac, Perthro is unlocked by unlocking Solar System (Challenge).
Structured pathSource-backed requirements are mapped into trackable steps.
Rerolls all items in the room (the same effect as The D6).
What unlocking Perthro leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13