Isaac's Heart
ItemRebirthLocked
familiarGame ID 276★★★★
How do you unlock Isaac's Heart?
In The Binding of Isaac, Isaac's Heart is unlocked by earning the Isaac completion mark as The Lost (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. [Repentance] The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.
See the full unlock path for Isaac's Heart — 9 stepsWhat unlocking Isaac's Heart leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13