Genesis
ItemRepentanceLocked
activeGame ID 622★★★★
How do you unlock Genesis?
In The Binding of Isaac, Genesis is unlocked by earning the Ultra Greedier completion mark as Jacob & Esau on hard mode.
Structured pathSource-backed requirements are mapped into trackable steps.
Removes all of Isaac's items and pickups and takes him to a unique Clean Bedroom with some pickups and Chests and a passage to the next floor. For every item Isaac lost, he gets to take an item from a set of three.
See the full unlock path for Genesis — 5 stepsWhat unlocking Genesis leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13