Hypercoagulation
ItemRepentanceLocked
passiveGame ID 724★★★★
How do you unlock Hypercoagulation?
In The Binding of Isaac, Hypercoagulation is unlocked by earning the Delirium completion mark as Tainted Magdalene.
Structured pathSource-backed requirements are mapped into trackable steps.
After Isaac takes damage from an enemy or donates health, launches Red Hearts from Isaac that despawn after 1.5 seconds.
What unlocking Hypercoagulation leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13