Immaculate Conception
ItemAfterbirthLocked
familiarGame ID 413★★★★
How do you unlock Immaculate Conception?
In The Binding of Isaac, Immaculate Conception is unlocked by earning the Boss Rush completion mark as Lilith (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
See the full unlock path for Immaculate Conception — 7 stepsWhat unlocking Immaculate Conception leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13