Zodiac
ItemAfterbirthLocked
passiveGame ID 392★★★★
How do you unlock Zodiac?
In The Binding of Isaac, Zodiac is unlocked by earning the Ultra Greed completion mark as The Lost (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Gives Isaac a random zodiac item effect that changes every floor.
See the full unlock path for Zodiac — 9 stepsWhat unlocking Zodiac leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13