Progression route

The Path to Guppy's Eye

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The path to unlock Guppy's Eye in The Binding of Isaac has 3 steps.

3 requirements remaining0%

Path progress

Paths end with clear instructions for actions that cannot be tracked automatically.

Next steps

Cain (Achievement)
Cain (Character)
Cain (Character) → Mother (normal)

Guppy's Eye (Achievement)

Cain → Mother

How to reach Mother: Defeat Hush 3 times to unlock A Secret Exit. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. Collect Knife Piece 1 in Downpour/Dross II. Collect Knife Piece 2 in Mines/Ashpit II. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother.

Cain (Character)

Cain (Achievement)

How to unlock: Hold 55 Coins at one time

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