Progression route

The Path to Soul of Cain

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The path to unlock Soul of Cain in The Binding of Isaac has 5 steps.

5 requirements remaining0%

Path progress

Paths end with clear instructions for actions that cannot be tracked automatically.

Next steps

The Hoarder
Tainted Cain
Tainted Cain → Hush (normal)

Soul of Cain (Rune)

Soul of Cain (Achievement)

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Tainted Cain → Hush

How to reach Hush: Defeat Mom's Heart for the 10th time to unlock Blue Womb. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. Defeat Hush in Blue Womb.

Tainted Cain

The Hoarder

How to unlock: Use Red Key (etc.) to open the hidden closet in Home as Cain

Tainted Cain → Boss Rush

React Flow