Soul of Cain
RuneRepentanceLocked
How do you unlock Soul of Cain?
In The Binding of Isaac, Soul of Cain is unlocked by earning every normal-mode completion mark as Tainted Cain.
Structured pathSource-backed requirements are mapped into trackable steps.
Opens all doors in the room and creates a Red Room on all valid walls. This also destroys the mirror located in Downpour / Dross II.
See the full unlock path for Soul of Cain — 5 stepsWhat unlocking Soul of Cain leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13