Soul of Isaac

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How do you unlock Soul of Isaac?

In The Binding of Isaac, Soul of Isaac is unlocked by earning every normal-mode completion mark as Tainted Isaac.

Structured pathSource-backed requirements are mapped into trackable steps.

Rerolls all items in the room, but they cycle back to the original item after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.

See the full unlock path for Soul of Isaac — 5 steps

Soul of Isaac (Achievement)
- All of
  - Tainted Isaac → Hush (normal)
    1. Defeat Mom's Heart for the 10th time to unlock Blue Womb. source
    2. Defeat Mom's Heart or It Lives! within 30 minutes and enter the door to Blue Womb. source
    3. Defeat Hush in Blue Womb. source
  - Tainted Isaac → Boss Rush (normal)

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What unlocking Soul of Isaac leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13