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Apollyon's Best Friend

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How do you unlock Apollyon's Best Friend?

In The Binding of Isaac, Apollyon's Best Friend is unlocked by earning the Mother completion mark as Tainted Apollyon.

Structured pathSource-backed requirements are mapped into trackable steps.

Spawns an Abyss locust familiar which will fly forward while Isaac shoots.

Apollyon's Best Friend (Achievement)
- Tainted Apollyon → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Tainted Apollyon

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What unlocking Apollyon's Best Friend leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13