Locust of Pestilence
TrinketAfterbirth+Locked
How do you unlock Locust of Pestilence?
In The Binding of Isaac, Locust of Pestilence is unlocked by earning the Satan completion mark as Apollyon (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.
See the full unlock path for Locust of Pestilence — 5 stepsWhat unlocking Locust of Pestilence leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13