Locust of War
TrinketAfterbirth+Locked
How do you unlock Locust of War?
In The Binding of Isaac, Locust of War is unlocked by earning the Isaac completion mark as Apollyon (Character).
Structured pathSource-backed requirements are mapped into trackable steps.
Upon entering a room with enemies for the first time, spawns a Red Locust which detonates upon impact with enemies.
See the full unlock path for Locust of War — 5 stepsWhat unlocking Locust of War leads to
Nothing depends on this yet.
Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13