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Guppy's Eye

ItemRepentanceLocked

passiveGame ID 665★★★★

How do you unlock Guppy's Eye?

In The Binding of Isaac, Guppy's Eye is unlocked by earning the Mother completion mark as Cain (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Shows the contents of Chests, Fire Places, Grab Bags, and Shopkeepers before they're opened/destroyed.

Guppy's Eye (Achievement)
- Cain (Character) → Mother (normal)
  1. Defeat Hush 3 times to unlock A Secret Exit. source
  2. After A Secret Exit is unlocked, a locked door to Downpour appears after completing Basement/Cellar/Burning Basement I or II. source
  3. Collect Knife Piece 1 in Downpour/Dross II. source
  4. Collect Knife Piece 2 in Mines/Ashpit II. source
  5. After defeating Mom in Mausoleum/Gehenna II, stab the flesh door that appears with the knife familiar to open it. source
  6. Defeat the Mausoleum version of Mom's Heart behind the flesh door, then reach Corpse II and defeat Mother. source
  - Cain (Character)

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What unlocking Guppy's Eye leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13