Black Rune
RuneAfterbirth+Locked
How do you unlock Black Rune?
In The Binding of Isaac, Black Rune is unlocked by earning the Ultra Greedier completion mark as Apollyon (Character) on hard mode.
Structured pathSource-backed requirements are mapped into trackable steps.
Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades.
See the full unlock path for Black Rune — 5 stepsWhat unlocking Black Rune leads to
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Source: bindingofisaacrebirth.wiki.gg
Imported 2026-09-13