Karma

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How do you unlock Karma?

In The Binding of Isaac, Karma is unlocked by earning the The Lamb completion mark as Keeper (Character).

Structured pathSource-backed requirements are mapped into trackable steps.

Donating to a Donation Machine, Blood Donation Machine, or Confessional has a chance to heal Isaac for a full Red Heart or spawn a Beggar. Increases the chance that donating to a Donation Machine will increase Isaac's luck.[Repentance+] Reduces the chance of the Donation Machine jamming. Donating to a Beggar has a chance to heal Isaac for a full Red Heart or increase luck.

See the full unlock path for Karma — 5 steps

Karma (Achievement)
- Keeper (Character) → The Lamb (normal)
  1. Defeat Satan 5 times to unlock The Negative. source
  2. The Negative is a guaranteed drop from Mom; take it, then defeat Satan in Sheol and touch the chest to enter Dark Room. source
  3. Find and defeat The Lamb in Dark Room. source
  - Keeper (Character)

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What unlocking Karma leads to

Nothing depends on this yet.

Source: bindingofisaacrebirth.wiki.gg

Imported 2026-09-13